#Emconf: Opioid Toxicities and Overdose Complications
Thu, 04/13/2017 - 6:10am
Specific Opioid Toxicities and Overdose Complications:
- Dextromethorphan
-Serotonin syndrome: triad of AMS/agitation, autonomic instability including hyperthermia, and neuromuscular abnormality with clonus/hyperreflexia
- Fentanyl
-Chest wall rigidity in thoracic and abdominal musculature: difficult to ventilate, possible reversal with narcan
- Hydrocodone and oxycodone
-Often contains acetaminophen
-Some suggestion oxycodone leads to prolonged QTc
- Loperamide
-National poison center: 71% increase in loperamide overdose cases from 2011 to 2015
-Often taken to aid withdrawal symptoms (occasionally as recreational high)
- Cardiac dysrhythmias: prolonged QT and QRS widening (K+ and Na+ channel blockade)
-Treatment: Mag sulfate, Na bicarb, isoproterenol, overdrive pacing
- Methadone
-Very long acting Half life 27 +/- 12 hours
-QTc prolongation
- Tramadol
-Seizures, typically occur in first 24 hours after using medication (~80-90%)
-GTC seizures, more common in those also using etoh, anti-depressants, anti-psychotics, other substances
References:
-Boostani, Reza and Siavash Derakhshan. “Tramadol induced seizure: A 3-year study.”
-Caspian J Internal Medicine. 2012 Summer; 3(3): 484–487. Burns, G et al. “Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse?” Clinical Toxicology. 2016 Jun;54(5):420-3
-Eggleston et al. “Loperamide Abuse Associated With Cardiac Dysrhythmia and Death.” Annals of Emergency Medicine. Jan 2017 Vol 69 Issue 1. 83-86