Local Anesthetic Systemic Toxicity
Mon, 02/10/2020 - 5:00am
Editor:
Systemic Toxicity of Local Anesthetics - how a simple laceration repair can go wrong
Mechanism of action of local anesthetics - sodium channel blockade inhibits propagation of nerve impulses
Toxicity occurs due to systemic effects of meds in a dose-related fashion
- Longer acting = higher risk of systemic toxicity (bupivacaine > lidocaine)
- Dosage limits of common agents:
- Lidocaine - 4mg/kg vs 7mg/kg with epinephrine
- Bupivacaine - 3mg/kg vs 5mg/kg with epinephrine
Signs and symptoms of toxicity:
- Vague neuro symptoms - tongue numbness, lightheadedness, visual and auditory hallucinations, twitching
- Can progress to refractory seizures and cardiovascular collapse
- Usually occurs within minutes of injection
Management
- ABC’s
- Benzodiazepines for seizures
- IV 20% lipid emulsion - 1.5mL/kg over 1 min then w/ continuous infusion/repeat dosage every 3 min until improved clinically (max of 10mL/kg over 30min); dosage variable depending on source referenced
Prevention
- Calculate dose limits, especially if repair of large/many lacerations or if performing larger volume regional block
- Always aspirate prior to infiltration of anesthetic agent to avoid injecting directly into vasculature.
Dillon, D, Gibbs, M. “Local and Regional Anesthesia.” Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8eEds. Judith E. Tintinalli, et al. New York, NY: McGraw-Hill, 2016.